The Colombian Exchange was a big change of animals, plants, human, populations, communicable disease and idea between Eastern and Western. It was the most significant for ecology, agriculture, and culture for human history. The Colombia Exchange affected almost every society on Earth. New diseases introduced by European, the Colombia population in the America is unclear, the disease include population losses 50 to 90 percent. The environment also changed, and made the global warming and little ice age. This exchange of plants and animals transformed European, American, African, and Asian ways of life. Like potatoes, it was not planted outside of South America. Many new plants coming and spread were changed many people’s life, also influence that area’s population.